Disparities in Hepatocellular Carcinoma Incidence in California: An Update
Menée à partir des données du registre californien des cancers sur la période 1988-2014, cette étude analyse l'évolution des disparités ethniques dans l'incidence du carcinome hépatocellulaire (47 992 cas)
Background: Given changes in hepatocellular carcinoma (HCC) incidence and the ethno-demographic landscape, we analyzed recent HCC incidence patterns and trends in California. Methods: Using 47,992 primary, invasive HCC cases diagnosed 1988-2014 from the California Cancer Registry, we calculated age-adjusted incidence rates (IRs), annual percent change (APC), and 95% confidence intervals (CIs), by sex, race/ethnicity, and nativity among Hispanics and Asian ethnic groups. Results: Compared to non-Hispanic Whites (NHWs), all other racial/ethnic groups had higher HCC incidence. Vietnamese had the highest IRs (males: 47.4, 95% CI = 45.3 to 49.5, females: 14.1, 95% CI = 13.0 to 15.3). Foreign-born Chinese, Japanese, Korean, and Vietnamese had higher incidence than U.S.-born. The reverse was observed for Hispanic males while no differences by nativity was seen for Hispanic females. IRs increased most for NHWs. Among Asians, male and female Filipinos and Japanese males experienced rate increases, while male and female Koreans and Chinese males experienced rate decreases. U.S.-born male and female Hispanics and Japanese had higher APCs than foreign-born, as did Filipino males, while Chinese males had a reverse pattern. Annual increases in HCC incidence slowed down in recent years for U.S.-born Hispanic males and females and stabilized among male NHWs and non-Hispanic Blacks. For some Asian groups, early time periods exhibited increasing/stable APCs while later time periods showed decreasing APCs. Conclusions: We found significant racial/ethnic and nativity differences in HCC IRs and trends. Impact: With changing trends, closer surveillance of HCC incidence by disaggregated race/ethnicity and nativity is warranted among Hispanics and Asians.