Incidence and clearance of anal HPV-16 and HPV-18 infection, and their determinants, among HIV-infected men who have sex with men in France
Menée en France sur la période 2014-2018 à partir de données portant sur 438 hommes ayant des relations homosexuelles et infectés par le VIH, cette étude prospective analyse les facteurs associés à l'incidence d'une infection par le papillomavirus humain de type 16 ou 18 et à la persistance de cette infection
Prospective data on the natural history of anal HPV infection are scarce in HIV-infected men who have sex with men (MSM). We analyzed incidence and clearance of HPV-16 and HPV-18 in a French cohort of HIV-infected MSM, aged ≥35 years, followed-up annually (n=438, 2014-2018). HPV-16 and HPV-18 incidence were similar (~10% incident infections at 24 months). HPV-16 incidence was higher among high-grade versus no lesion at baseline (aIRR=3.0;95%CI=1.07-8.18). HPV-16 cleared significantly slower than HPV-18 (32% versus 54% by 24 months). In conclusion, anal HPV-16 is more persistent than HPV-18, and its incidence correlates with a prior detection of high-grade lesions.