Development of cancer metabolism as a therapeutic target: new pathways, patient studies, stratification and combination therapy
Ce dossier présente une série d'articles concernant le métabolisme des cellules cancéreuses, notamment les processus métaboliques susceptibles de constituer des cibles thérapeutiques
Cancer metabolism has undergone a resurgence in the last decade, 70 years after Warburg described aerobic glycolysis as a feature of cancer cells. A wide range of techniques have elucidated the complexity and heterogeneity in preclinical models and clinical studies. What emerges are the large differences between tissues, tumour types and intratumour heterogeneity. However, synergies with inhibition of metabolic pathways have been found for many drugs and therapeutic approaches, and a critical role of window studies and translational trial design is key to success.
British Journal of Cancer , éditorial en libre accès, 2019