Carcinoembryonic antigen-specific, fluorescent image-guided cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for metastatic colorectal cancer
Menée sur 14 patients présentant des métastases péritonéales ayant pour origine un cancer colorectal, cette étude multicentrique évalue la faisabilité d'un traitement combinant une chirurgie cytoréductive, guidée par une technique d'imagerie en fluorescence utilisant des anticorps ciblant l'antigène carcino-embryonnaire, et une chimiothérapie intrapéritonéale hyperthermique
This multicentre pilot study investigated the role of peroperative carcinoembryonic antigen (CEA)-specific fluorescence imaging during cytoreductive surgery?hyperthermic intraperitoneal chemotherapy surgery in peritoneal metastasized colorectal cancer. A correct change in peritoneal carcinomatosis index (PCI) owing to fluorescence imaging was seen in four of the 14 included patients. The use of SGM-101 in patients with peritoneally metastasized colorectal carcinoma is feasible, and allows intraoperative detection of tumour deposits and alteration of the PCI. Augmented reality guidance