Total antioxidant capacity and pancreatic cancer incidence and mortality in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Menée aux Etats-unis auprès de 96 018 personnes incluses dans l'essai "Prostate, Lung Colorectal and Ovarian Cancer Screening Trial", cette étude analyse l'association entre la capacité antioxydante totale (antioxydants d'origine alimentaire et supplémentation) et le risque de cancer du pancréas (393 cas) et la mortalité associée (353 décès)
Background: Total antioxidant capacity (TAC) reflects an individual's overall antioxidant intake. We sought to clarify whether higher TAC is associated with lower risks of pancreatic cancer incidence and mortality in the US general population. Methods: A total of 96018 American adults were identified from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. A ferric reducing ability of plasma score was used to reflect an individual's TAC intake from diet and/or supplements. Cox regression was used to calculate hazard ratios for pancreatic cancer incidence and competing risk regression was used to calculate sub-distribution hazard ratios for pancreatic cancer mortality. Restricted cubic spline regression was used to test nonlinearity. Results: A total of 393 pancreatic cancer cases and 353 pancreatic cancer deaths were documented. Total (diet + supplements) TAC was found to be inversely associated with pancreatic cancer incidence (hazard ratio quartile 4 vs quartile 1 0.53; 95% confidence interval 0.39-0.72; Ptrend=0.0002) and mortality (sub-distribution hazard ratio quartile 4 vs quartile 1 0.52; 95% confidence interval 0.38-0.72; Ptrend=0.0003) in a non-linear dose-response manner (all Pnon-linearity<0.01). Similar results were observed for dietary TAC. No association of supplemental TAC with pancreatic cancer incidence and mortality was found. Conclusions: In the US general population, dietary but not supplemental TAC level is inversely associated with risks of pancreatic cancer incidence and mortality in a non-linear dose-response pattern.