Prevalence of HPV and pathological changes among women 70 years of age, 10 years after exclusion from the Swedish cervical cancer screening program
Menée en Suède auprès de 1 968 femmes nées en 1946 et invitées à réaliser, 10 ans après leur dernière participation à un programme de dépistage du cancer du col utérin, un test de rechercherche de l'ARN messager des papillomavirus humains à haut risque (hrHPV), cette étude évalue la prévalence des hrHPV ainsi que le taux de lésions malpighiennes intraépithéliales de bas grade et de haut grade
Purpose : Örebro County introduced an updated screening program 2016 with primary HPV test for women over 30 years and prolonged screening, increasing the cut-off age from 56–60 to 64–70. The aim of this study was to investigate the prevalence of HPV genotypes and their correlation to histological changes in women, 10 years after exclusion from the screening program, due to an eventual implementation of a catch-up program including all women aged 60–70.
Methods : All women in Örebro County, born 1,946 (n = 1,968), were invited to a liquid-based cell sample with primary HPV screening. Samples were analyzed for hrHPV mRNA and positive samples were genotyped. hrHPV positive women were offered to do a conization.
Results : Out of 809 participants, 31 (3.8%) were hrHPV positive, of these 22 did a conization. Histologically, 5/22 (23%) had LSIL and 5/22 (23%) had HSIL. Normal histology was found in 12/22 (55%). The most prevalent genotypes were HPV 16, 33, 52, 56, and 68. Of the women with HSIL, one case of cervical cancer was confirmed in a recone biopsy after 4 months.
Conclusion : The study showed considerable prevalence of hrHPV and histologically confirmed LSIL/HSIL. These data led to catch-up screening for women between 60 and 70 years when overlapping two screening strategies.
Cancer Causes & Control , article en libre accès, 2020