Magnesium intake and primary liver cancer incidence and mortality in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Menée aux Etats-Unis par questionnaire auprès de 104 025 participants inclus dans l'essai "Prostate, Lung Colorectal and Ovarian Cancer Screening Trial" (âge : 55-74 ans ; durée moyenne de suivi : 11,5 ans), cette étude analyse l'association entre un apport en magnésium provenant de l'alimentation ou de suppléments et l'incidence du cancer primitif du foie (116 cas) ainsi que la mortalité associée (100 décès)
Epidemiological studies on magnesium intake and primary liver cancer (PLC) are scarce, and no prospective studies have examined the associations of magnesium intake with PLC incidence and mortality. We sought to clarify whether higher magnesium intake from diet and supplements was associated with lower risks of PLC incidence and mortality in the US population. Magnesium intake from diet and supplements was evaluated through a food frequency questionnaire in a cohort of 104,025 participants. Cox regression was employed to calculate hazard ratios for PLC incidence and competing risk regression was employed to calculate sub-distribution hazard ratios for PLC mortality. Restricted cubic spline regression was employed to test nonlinearity. We documented 116 PLC cases during 1,193,513.5 person-years of follow-up and 100 PLC deaths during 1,198,021.3 person-years of follow-up. Total (diet + supplements) magnesium intake was found to be inversely associated with risks of PLC incidence (hazard ratiotertile 3 vs 1: 0.44; 95% confidence interval: 0.24, 0.80; Ptrend = 0.0065) and mortality (sub-distribution hazard ratiotertile 3 vs 1: 0.37; 95% confidence interval: 0.19, 0.71; Ptrend = 0.0008). Similar results were obtained for dietary magnesium intake. Non-linear inverse dose–response associations with PLC incidence and mortality were observed for both total and dietary magnesium intakes (all Pnon-linearity < 0.05). In summary, in the US population, a high magnesium intake is associated with decreased risks of PLC incidence and mortality in a non-linear dose–response manner. These findings support that increasing the consumption of foods rich in magnesium may be beneficial in reducing PLC incidence and mortality. This article is protected by copyright. All rights reserved.