Associations of novel dietary and lifestyle inflammation scores with incident colorectal cancer in the NIH-AARP Diet and Health Study
Menée aux Etats-Unis à partir de données portant sur 453 465 individus (durée moyenne de suivi : 13,5 ans), cette étude analyse l'association entre des indicateurs caractérisant le potentiel inflammatoire de l'alimentation ou du mode de vie et le risque de cancer colorectal (10 336 cas)
Chronically higher inflammation, likely contributed to by dietary and lifestyle exposures, may increase risk for colorectal cancer (CRC). To address this, we investigated associations of novel dietary (DIS) and lifestyle (LIS) inflammation scores with incident CRC in the prospective National Institutes of Health-American Association of Retired Persons (NIH-AARP) Diet and Health Study (N = 453,465).The components of our previously developed and externally validated 19-component DIS and 4-component LIS were weighted based on their strengths of associations with a panel of circulating inflammation biomarker concentrations in a diverse subset (N = 639) of participants in the REasons for Geographic and Racial Differences in Stroke Study cohort. We calculated the components and applied their weights in the NIH-AARP cohort at baseline, summed the weighted components (higher scores reflect a higher balance of pro-inflammatory exposures), and investigated associations of the scores with incident CRC using Cox proportional hazards regression. All statistical tests were two-sided.Over a mean 13.5 years of follow-up, 10,336 participants were diagnosed with CRC. Among those in the highest relative to the lowest DIS and LIS quintiles, the multivariable-adjusted hazards ratios (HR) and their 95% confidence intervals [CI]) were: 1.27 (95% CI: 1.19-1.35; Ptrend <0.001) and 1.38 (95% CI: 1.30-1.48; Ptrend <0.001), respectively. The associations were stronger among men and for colon cancers. The HR for those in the highest relative to the lowest joint DIS/LIS quintile was 1.83 (95% CI: 1.68-1.99; Pinteraction <0.001).Aggregates of pro-inflammatory dietary and lifestyle exposures may be associated with higher risk for CRC.
JNCI Cancer Spectrum 2020