Dietary Intakes of Trace Elements and the Risk of Kidney Cancer: The Singapore Chinese Health Study
Menée en Chine par questionnaire auprès de 63 257 individus et à l'aide de données du registre des cancers (âge moyen : 56,9 ans ; durée médiane de suivi : 20,1 ans), cette étude analyse l'association entre un apport alimentaire de zinc, de cuivre ou de manganèse et le risque de cancer du rein (229 cas)
Background: Epidemiological studies have demonstrated separately that patients with kidney stone may have higher dietary intake of zinc and higher risk of developing kidney cancer. We prospectively assessed the associations of dietary zinc and other trace elements with kidney cancer risk for the first time. Methods: We used data from the prospective Singapore Chinese Health Study that recruited 63,257 adult Chinese residing in Singapore between 1993 and 1998. A validated food frequency questionnaire and the Singapore Food Composition Database was used to compute the values of intake for zinc, copper and manganese. We identified incident cancer cases via linkage with nationwide cancer registry, and used Cox proportional hazard models to compute hazard ratio (HR) and 95% confidence interval (CI) for the association with kidney cancer risk. Results: There were 229 incident kidney cancer cases after median follow-up of 20.1?years. Dietary zinc intake was positively associated with higher kidney cancer risk; the HR comparing the extreme quartiles of zinc intake was 1.74 (95% CI: 1.02-2.97; P-trend = 0.033). Conversely, intakes of copper and manganese were not associated with kidney cancer risk. Conclusions: The positive association between dietary zinc and risk of kidney cancer suggests that zinc may be implicated in renal carcinogenesis.