Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention
Menée à partir d'échantillons sanguins prélevés sur 10 006 participantes, cette étude évalue la faisabilité, en pratique clinique de routine, et la sécurité d'un test de dépistage de plusieurs types de cancers suivi, si positif, d'une tomographie numérique par émission de positrons
Cancer treatments are often more successful when the disease is detected early. We evaluated the feasibility and safety of multi-cancer blood testing coupled with PET-CT imaging to detect cancer in a prospective, interventional study of 10,006 women not previously known to have cancer. Positive blood tests were independently confirmed by a diagnostic PET-CT, which also localized the cancer. Twenty-six cancers were detected by blood testing. Of these, 15 underwent PET-CT imaging and nine (60%) were surgically excised. Twenty-four additional cancers were detected by standard-of-care screening and 46 by neither approach. 1.0% of participants underwent PET-CT imaging based on false positive blood tests, and 0.22% underwent a futile invasive diagnostic procedure. These data demonstrate that multi-cancer blood testing combined with PET-CT can be safely incorporated into routine clinical care, in some cases leading to surgery with intent to cure.
Science , résumé, 2019