The relative impact of urinary and sexual function versus bother on health utility for men with prostate cancer
Menée aux Etats-Unis à partir de données portant sur 1 617 patients atteints d’un cancer de la prostate, cette étude analyse l’effet de la maladie sur les fonctions urinaire et sexuelle et sur la gêne occasionnée, puis compare l’intérêt de ces deux critères (fonctions et gêne) dans l’évaluation de la qualité de vie
Function and bother are related but distinct aspects of health-related quality of life (HRQoL). The objective of this study was to compare quantitatively the relative impacts of function and bother in urinary, sexual, and bowel outcomes on health utility as a reflection of HRQoL in men with prostate cancer. Our analysis included participants in the Cancer of the Prostate Strategic Urologic Research Endeavor utility supplementary study, with a final cohort of 1,617 men. Linear regression on the patients’ function and bother summary scores (0-100) from the University of California, Los Angeles Prostate Cancer Index was performed to predict bias-corrected health utilities. Urinary and sexual bother were significantly associated with each health utility, and their coefficients were 3.7 and 20.8 times greater than those of the corresponding function. To our knowledge, our study provides the first quantitative and direct comparison of the impacts of function versus bother on health utility
JNCI Cancer Spectrum 2020