Association between Dietary Zinc and Selenium Intake, Oxidative Stress-Related Gene Polymorphism, and Colorectal Cancer Risk in Chinese Population - A Case-Control Study
Menée en Chine par questionnaire et à l'aide d'échantillons sanguins collectés auprès de 498 témoins et 493 patients atteints d'un cancer colorectal (âge moyen : 57,7 ans), cette étude analyse l'association entre un apport alimentaire de zinc et de sélénium, seuls ou combinés, des polymorphismes des gènes liés au stress oxydant et le risque de développer la maladie
Zinc and selenium may protect against colorectal cancer (CRC) progression through their anti-oxidative effects. This study examined the independent and combined effect of dietary zinc and selenium intake, and polymorphisms of the oxidative stress-related genes (superoxide dismutase 1, superoxide dismutase 2, glutathione peroxidase, and catalase) on CRC risk in a Chinese case-control study. A total of 493 cases and 498 sex and age-matched controls were randomly selected from an ongoing case-control study. Dietary information was assessed through face-to-face interviews using a validated food frequency questionnaire. Multiplex PCR-ligase detection reaction was used for genotyping the target SNPs. Multivariable logistic regression was used to estimate the odds ratios (ORs) and 95% confidence interval (CI). Intake of selenium was found to be inversely associated with CRC risk, while zinc was not associated with CRC risk. The ORs (95% CI) for the highest vs. the lowest quartile were 0.42 (95% CI 0.28, 0.64, P trend < 0.001) for selenium and 0.96 (95% CI 0.63, 1.47, P trend = 0.505) for zinc. Combined effect was observed between zinc and SOD1 rs4998557 on CRC risk (P interaction < 0.05). This study identified a novel diet-gene interaction in the oxidative stress pathway on CRC risk in Chinese population.
Nutrition and Cancer 2020