Association between family history of lung cancer and lung cancer risk: a systematic review and meta-analysis
A partir d’une revue systématique de la littérature publiée jusqu’en octobre 2019 (85 études), cette méta-analyse évalue les disparités géographiques dans l’association entre des antécédents familiaux de cancer du poumon et le risque de développer la maladie
Background : Familial risk of lung cancer has been widely studied but the effects of socio-demographic factors and geographical regions are largely unknown. Methods : PubMed and Embase were systematically searched until 1 st October 2019. A total of 85 studies (19 cohort and 66 case control studies) were included in this systematic review and meta-analysis. Pooled summary estimates and 95% confidence intervals were estimated, and the analysis was stratified by socio-demographics and geographical regions. Results : Geographical regions, gender, age of proband, smoking status, type of first-degree relatives, number of affected relatives, and early onset of lung cancer in affected relatives were significant determinants of familial risk of lung cancer. Higher risk of familial lung cancer was found among Asians as compared to non-Asians, younger individuals (age?50) as compared with older individuals (age>50), individuals with ?2 affected relatives as compared with individuals with one affected relative, ever-smokers as compared with never-smokers, Asian females as compared with Western females, and never-smokers in Asia as compared with never-smokers in the West. Conclusions : Familial risk of lung cancer is influenced by both genetic and environmental factors. Future studies should control for environmental factors such as air pollution and environmental tobacco smoke which are prevalent in Asia.