Concurrent and Concordant Oral and Genital High-Risk Human Papillomavirus in the U.S.: Results from the National Health and Nutrition Examination Survey
Menée aux Etats-Unis entre 2009 et 2016 par enquête auprès de 3 241 hommes et 7 093 femmes, cette étude analyse la prévalence d'une infection orale et génitale par le papillomavirus humain et les facteurs associés, en fonction du sexe
Oropharyngeal cancers associated with high-risk human papillomavirus (HR-HPV) infection are increasing in the U.S., especially among men. We evaluated prevalence and predictors of concurrent (genital and oral) and concordant (same-type) HR-HPV infections in U.S.We used National Health and Nutrition Examination Survey from 2009-2016. Predictors were assessed via multivariable logistic regression.Among 10,334 respondents, 172 (2.1%) had concurrent infections [109 (3.5%) men and 63 (0.76%) women]. Ninety-three (1.0%) had concordant infections [54 (1.6%) men and 39 (0.5%) women]. Predictors of concurrence in men were: no longer married vs. married [2.3 (OR); 1.3-4.9 (95% CI)], living with a partner vs. married [3.0; 1.2-7.5], and having 2-5 lifetime oral sex partners [3.0; 1.2-7.5]. In women they were: no longer married vs. married [3.6; 1.3-10.3], ≥2 recent sex partners [4.6; 1.4-15.6 for 2-5 partners and 3.9; 1.1-14.3 for 6+ partners], and marijuana use [2.2; 1.0-4.5]. The predictor of concordance in men and women was no longer married vs. married [3.5; 1.2-9.9 in men and 3.2; 1.1-9.4 in women].Concurrent and concordant HR-HPV infections occur at a high rate, especially among men, and are associated with behavioral factors. This underscores the importance of HPV vaccination, screening, and education in men.