Body mass index and height in relation to brain tumor risk in a Japanese population
Menée au Japon à partir de données portant sur 102 925 participants, cette étude de cohorte prospective analyse l'association entre l'indice de masse corporelle, la taille, et le risque de tumeur du cerveau
Purpose : Although height and BMI are reported to be positively associated with several common cancers, evidence regarding their association with brain tumor risk remains sparse, particularly in Asian populations. In this study, we analyzed the association between height and BMI and brain tumor risk in a Japanese population using a large population-based prospective cohort study. Method : A total of 102,925 subjects (48,213 men and 54,712women) enrolled in the Japan Public Health Center-based Prospective Study (JPHC Study) was followed from baseline, namely 1990 for cohort I and 1993 for cohort II, until 2012. Information on participants’ dietary and lifestyle habits, including height and body weight, were collected through survey questionnaires administered at baseline. We used the Cox proportional hazards regression model to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for brain tumor incidence, with adjustment for potential confounding variables. Results : During an average follow-up of 18.1 years, 157 (70 men and 87 women) cases of brain tumor were newly diagnosed. BMI showed a statistically insignificant positive association with the risk of brain tumor. In addition, statistically significant positive trends were seen for men and meningioma, with multivariable-adjusted HRs for a BMI of 27.5-<40 versus 18.5-<23 kg/m2 of 2.14 (95% CI= 0.99-4.59) (P=0.03) and 1.98 (95% CI= 0.84-4.67) (P=0.046), respectively. In contrast, height showed no clear association with brain tumor risk, overall or in subgroup analysis. Conclusion : Compared to a BMI of 18-<23.5 kg/m2, higher BMI was associated with higher risk of brain tumor, particularly in men and with meningioma.