Associations of General Obesity and Central Obesity with the Risk of Hepatocellular Carcinoma in a Korean Population: A National Population-Based Cohort Study
Menée en Corée à partir de 2009 auprès de plus de 10,5 millions de participants (durée moyenne de suivi : 7,3 ans), cette étude analyse l'association entre le tour de taille ("obésite centrale"), l'indice de masse corporelle ("obésité générale") et le risque de carcinome hépatocellulaire (26 979 cas)
Numerous previous studies have shown an association between general obesity and hepatocellular carcinoma (HCC). However, relatively few reports on the association of central obesity and HCC are available in Asian populations. Therefore, we investigated the association between WC representing central obesity and the risk of HCC in addition to BMI representing general obesity and the risk of HCC in Korea. A total of 10,505,818 participants who received the National Health Insurance Service (NHIS) health checkups in 2009 were screened for study eligibility, and 26,979 cases of HCC occurred during the 7.3 years of mean follow-up. General obesity increased the risk of HCC with hazard ratios (HRs) of 1.14 (95% CI, 1.11-1.18) for BMI 25.0-<30.0 kg/m2 and 1.52 (95% CI, 1.43-1.61) for BMI ≥30 kg/m2 compared with those whose BMI is within the normal range. Central obesity was also associated with a higher risk of HCC. For the participants with a WC ≥105 cm in men and WC ≥100 cm in women, the risk of HCC was higher than that of the reference group (HR=1.69, 95% CI, 1.54-1.85). The HRs were 1.13 (95% CI, 1.07-1.19) for nonobese participants with central obesity, and 1.34 (95% CI, 1.30-1.38) for obese participants with central obesity compared to those without both conditions. Our findings suggest that the risk of HCC increases even more when general obesity is combined with central obesity. Moreover, central obesity is associated with the risk of HCC, regardless of general obesity.