The delicate balancing act of childhood cancer treatment—not too much but not too little
Menée à partir des données d'une cohorte américaine et d'une cohorte britannique incluant respectivement 31 596 et 18 226 patients ayant survécu à un cancer pédiatrique diagnostiqué avant l'âge de 15 ans sur la période 1970-1999, cette étude analyse les facteurs associés au risque de décès et les causes de mortalité
The treatment of childhood cancer is a success story. As a result of marked advances in treatments, death rates from the major types of childhood cancer in the United States (U.S.) have decreased by more than 60% over the past several decades, from 6.3 per 100,000 population in 1970 to 2.0 per 100,000 population in 2017 (1). Today, the overall 5-year relative survival for individuals diagnosed with a childhood cancer exceeds 80% survival, compared to 68% in the mid-1970s (1). While childhood cancer incidence rates are generally higher among Whites compared to Blacks, mortality rates are similar, with a noted disparity in the overall 5-year relative survival rate between Blacks (80.9%) and Whites (86.5%) for those aged 0-14 years at diagnosis
Journal of the National Cancer Institute , éditorial en libre accès, 2019