Unravelling the etiology of early-onset colorectal cancer
Menée à partir de données 1991-2011 de la cohorte "the Nurses’ Health Study" portant sur 29 474 femmes ayant passé au moins 1 endoscopie avant l'âge de 50 ans, cette étude analyse l'association entre la qualité de l'alimentation et le risque de développer un adénome colorectal (1 157 cas)
Colorectal cancer incidence and mortality rates are stabilizing or falling in many highincome countries primarily due to advances in screening, surveillance, and treatment. In the U.S., for example, from 1975 to 2015 the incidence of colorectal cancer declined by 37% while deaths from the disease fell by approximately 50%. In contrast, colorectal cancer incidence in younger adults(diagnosed prior to age 50 years) has risen. From 1988 to 2015 age-adjusted early-onset colorectal cancer incidence rates in the U.S rose from 7.9 to 12.9 cases per 100,000 people - corresponding to a 63% increase. This divergent pattern of incidence for overall and early-onset colorectal cancer incidence is mirrored in other highincome countries, including Australia, Canada, Germany, and Sweden.
Journal of the National Cancer Institute , commentaire en libre accès, 2019