Pre- and post-diagnosis diet quality and ovarian cancer survival
Menée aux Etats-Unis par questionnaire auprès de patientes atteintes d'un cancer de l'ovaire (650 et 503 cas), cette étude analyse l'association entre la qualité de l'alimentation, mesurée avant puis 12 mois après le diagnostic, et la survie (durée médiane de suivi : 4,4 ans ; 278 décès)
Background: Prior studies evaluating diet quality in relation to ovarian cancer survival are sparse, and to date none have assessed diet quality or diet quality change after diagnosis. Methods: In the prospective Ovarian cancer Prognosis And Lifestyle (OPAL) study, diet quality scores were calculated using data from food frequency questionnaires completed pre-diagnosis (n=650) and 12 months post-diagnosis (n=503). We used Cox proportional hazard models to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the association between diet quality and survival. Results: 278 women died from ovarian cancer during the median follow up of 4.4 years. There was no evidence of an association between diet quality pre- or post-diagnosis and progression-free, overall or ovarian cancer-specific survival. No survival advantage was observed for women who had either improved their diet quality or who consumed a high quality diet both before and 12 months after diagnosis. Conclusion: Higher pre- and post-diagnosis diet quality was not associated with better survival outcomes in this cohort of women with ovarian cancer. Impact: Diet quality is important for a range of health outcomes but may not improve survival after a diagnosis of ovarian cancer.