Glioblastoma stem cells induce quiescence in surrounding neural stem cells via Notch signaing
Menée à l'aide de cellules souches neuronales de souris, cette étude démontre que les cellules souches de glioblastome induisent la quiescence des cellules souches neuronales environnantes via la voie de signalisation de Notch
There is increasing evidence demonstrating that adult neural stem cells (NSCs) are a cell of origin of glioblastoma. Here we analyzed the interaction between transformed and wild-type NSCs isolated from the adult mouse subventricular zone niche. We found that transformed NSCs are refractory to quiescence-inducing signals. Unexpectedly, we also demonstrated that these cells induce quiescence in surrounding wild-type NSCs in a cell–cell contact and Notch signaling-dependent manner. Our findings therefore suggest that oncogenic mutations are propagated in the stem cell niche not just through cell-intrinsic advantages, but also by outcompeting neighboring stem cells through repression of their proliferation.
Genes & Development 2020