T cell factor 1: A master regulator of the T cell response in disease
Cet article analyse le rôle du facteur de transcription TCF1 dans la régulation de la réponse des lymphocytes T durant les phases inflammatoires induites par certaines maladies, en particulier les maladies autoimmunes, les infections chroniques et les cancers
Recent advances have redefined a role for T cell factor 1 (TCF1) that goes beyond T cell development and T memory formation and encompasses new functions in the regulation of T cell biology. Here, we discuss the multifaceted and context-dependent role of TCF1 in peripheral T cells, particularly during disease-induced inflammatory states such as autoimmunity, cancer, and chronic infections. Understanding how TCF1 fine-tunes peripheral T cell biology holds the potential to tailor improved immune-targeted therapies.
Science Immunology , résumé, 2019