Putting Warburg to work: how imaging of tumour acidosis could help predict metastatic potential in breast cancer
Menée à l'aide de lignées cellulaires de cancer mammaire et de modèles murins, cette étude met en évidence une corrélation entre l'acidité de la tumeur, déterminée au moyen d'une IRM par transfert de saturation dépendant des échanges chimiques, et son potentiel métastatique
Solid tumours are often highly acidic compared to normal tissue, and tumour extracellular acidosis contributes to multiple aspects of cancer progression. Now, Anemone et al. in this issue of the British Journal of Cancer provide in vivo evidence that the degree to which various breast cancer cell lines acidify their environment correlates with their ability to metastasise to the lungs. This indicates that measurements of tumour extracellular acidosis have the potential to become a clinical tool for assessing the risk of metastasis.
British Journal of Cancer , éditorial en libre accès, 2020