Parental Occupation and Risk of Childhood Retinoblastoma in Denmark
Menée à l'aide des données 1975-2014 de 4 registres nationaux danois portant sur 144 patients pédiatriques atteints d'un rétinoblastome (diagnostiqué avant l'âge de 5 ans), cette étude analyse l'effet d'expositions professionnelles des parents sur le risque pour l'enfant de développer la maladie
Objective: Retinoblastoma is the most common primary intraocular tumor affecting children. We examine the role of parental occupational exposures and risk of retinoblastoma among offspring. Methods: Our population-based case-control study linked data from four nationwide Danish registries and included all cases of retinoblastoma diagnosed in Danish children (<5 years, n = 144) between 1975–2014. We focused on two biologically relevant time periods: 90 days preconception to conception for fathers; conception to birth for mothers. Parents were grouped into major industry headings created from Danish industry codes. Results: We observed increased risk of all retinoblastoma for children of fathers in the food and drink industry and iron and metal industry. Bilateral disease was associated with paternal work in manufacturing and land transportation. Conclusion: Our results suggest that some occupational exposures may increase the risk of childhood sporadic retinoblastoma.