Sugary drink consumption and subsequent colorectal cancer risk: the Japan Public Health Center-based Prospective Cohort Study
Menée au Japon entre 1995 et 1999 par questionnaire auprès de 74 070 personnes (âge moyen : 56,5 ans ; durée de suivi : 15 ans), cette étude analyse l'association entre une consommation de boissons sucrées et le risque de cancer colorectal (1 648 cas)
Background: Most studies examining the associations of sugary drink consumption on colorectal cancer risk have been conducted in Western populations. Methods: This study consisted of 74 070 participants in the Japan Public Health Center-based Prospective Study who completed a food frequency questionnaire (1995-1999). The participants were followed-up until December 2013 to investigate the associations between sugary drink consumption and colorectal cancer risk using Cox proportional hazards regression models. Results: Among the 74 070 participants, mean age was 56.5 years at baseline with a mean BMI of 23.5 and a mean daily consumption of 286 ml/d for men and 145 ml/d for women. During a follow-up of 15 years, 1 648 colorectal cancer cases were identified. No overall greater risk of colorectal cancer was observed among men (multivariable HR 0.84, 95%CI 0.70-1.02, {greater than or equal to}254ml/d vs. non-consumers) and women (HR 1.20, 95%CI 0.96-1.50, {greater than or equal to}134ml/d vs. non-consumers). Sugary drink consumption was associated with colon cancer among women (HR 1.36, 95%CI 1.03-1.78, {greater than or equal to}134ml/d vs. non-consumers). HRs for proximal colon cancer among women who consumed sugary drinks, as compared with non-consumers, were 1.47 (95% CI 1.03-2.10) for sugary drink consumption less than 134ml/d, and 1.45 (95% CI 1.01-2.09) for at least 134ml/d. Conclusion: In this large prospective cohort of Japanese with a moderate sugary drink consumption level and low prevalence of obesity, we observed a 36% increased risk of colon cancer in women. Impact: Our findings highlight the importance of subsite- and sex-specific investigation.