Advances in ovarian cancer, from biology to treatment
Cet article passe en revue les découvertes concernant les mécanismes biologiques et les traitements dans les cancers de l'ovaire
Recent preclinical and clinical research has led to exciting advances related to high-grade serous ovarian cancer, from examining its cellular origins to gaining insight into DNA-damage-repair mechanisms that may be leveraged for therapies. Furthermore, studies have demonstrated clinical benefit for inhibition of the polymerase PARP and modulation of the cell cycle, and have identified molecular features related to therapeutic response.
Nature Cancer , article en libre accès, 2020