Are Prediagnostic Biomarkers of Inflammation and an Empirically-Based Proinflammatory Dietary Pattern Associated with Poorer Pancreatic Cancer Survival?
Menée à partir de données portant sur 492 puis 1 153 patients ayant développé un cancer du pancréas, cette étude évalue l'association entre les niveaux plasmatiques de biomarqueurs de l'inflammation avant le diagnostic de la maladie et la survie des patients
Pancreatic cancer is a leading cause of cancer deaths, ranking third for mortality in the United States. Its incidence is increasing in the United States [1]and worldwide since the mid-1990s, particularly in developed countries [2]. As there are no effective screening methods for detection of this malignancy, it is typically diagnosed at advanced stages, when there is no cure, which contributes to a poor five-year survival rate of 10percent [1]. More than 80%of pancreatic cancer patients are diagnosed with metastatic disease or regional spread to the lymph nodes [1]. Identifying factors from which therapeutic strategies might bedeveloped couldhelp improvesurvival.Diet, in particular, is a potentially modifiable factor that is safe and patient-empowering.
Journal of the National Cancer Institute , commentaire en libre accès, 2020