Pre- and post-diagnosis leisure time physical activity and survival following diagnosis with ovarian cancer
Menée aux Etats-Unis à partir de données portant sur 1 461 patientes atteintes d'un cancer épithélial invasif de l'ovaire, cette étude de cohorte analyse l'association entre la pratique d'une activité physique de loisir, avant et après le diagnostic, et la survie
Little is known about the influence of pre- and post-diagnosis physical activity on ovarian cancer survival. We investigated this association in two large cohorts, the Nurses’ Health Study (NHS) and NHSII. Analyses included 1461 women with confirmed invasive, epithelial ovarian cancer and data on physical activity. Cox regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for ovarian cancer-specific mortality. Ovarian cancer-specific mortality was not associated with physical activity reported 1-8 years before diagnosis overall (≥7.5 vs. <1.5 MET-hours/week, HR=0.96), for high-grade serous/ poorly differentiated tumors, or non-serous/ low-grade serous tumors (P-heterogeneity=0.45). An inverse association was observed for activity 1-4 years after diagnosis (≥7.5 vs. <1.5 MET-hours/week, HR=0.67, 95%CI: 0.48-0.94), with similar results by histotype (P-heterogeneity=0.53). Women who decreased their activity from ≥7.5 MET-hours/week 1-8 years before diagnosis to <7.5 MET-hours/week 1-4 years after diagnosis, compared with those with <7.5 MET-hours/week across periods, had a 49% increased risk of death (HR=1.49, 95%CI: 1.07-2.08). Physical activity after, but not before, ovarian cancer diagnosis was associated with better prognosis.