Understanding Adiposity at Different Times across the Life Course and Cancer Risk: Is Evidence Sufficient to Act?
Cette étude analyse l'intérêt des études menées par randomisation mendélienne en comparaison avec les études observationnelles pour fournir des informations sur l'association entre l'obésité et le risque de cancer
Fang et al. raise several important considerations in understanding adiposity and cancer risk. First, the extensive summary of Mendelian randomization (MR) evidence helps bring together the literature on timing of adiposity in relation to cancer risk at different sites. Second, although 5 years ago the International Agency for Research on Cancer (IARC) evaluation of the cancer preventive effect of absence of excess body fatness concluded that there was sufficient evidence that absence of excess body fatness prevent cancers of the esophagus, gastric cardia, colon and rectum, liver, gallbladder, pancreas, postmenopausal breast cancer, corpus uteri, ovary, renal cell cancer of the kidney, meningioma, thyroid, and multiple myeloma in humans, since that report was published, the evidence has shown that childhood adiposity is inversely related to breast cancer. And third, despite these advances in understanding relations with adiposity, the mechanistic insights are not yet in place to translate these associations to pathways for prevention or interception of breast cancer.
Journal of the National Cancer Institute , éditorial en libre accès, 2020