Periodontal disease and breast cancer risk: Results from the Nurses' Health Study
Menée à partir de données 1998-2014 de la cohorte "the Nurses’ Health Study" portant sur 77 541 participantes (durée de suivi : 14 ans), cette étude analyse l'association entre la perte osseuse parodontale et le risque de cancer du sein (5 110 cas)
Background: While periodontal disease has been linked to increased cancer risk, studies regarding an association with breast cancer are limited. Methods: We examined the relationship between self-reported diagnosis of periodontal bone loss and incidence of breast cancer in a large, prospective cohort study, the Nurses' Health Study (1998-2014). We calculated hazard ratios using Cox proportional hazard modeling, adjusting for risk factors common to both periodontal disease and breast cancer. Results: During 1,023,647 person-years of follow-up, 5110 of breast cancer cases were reported. We observed no association between periodontal disease and overall breast cancer risk (HR 1.02, 95% CI: 0.94-1.10); the association was not modified by smoking status, or other breast cancer risk factors or by breast tumor subtypes. Conclusions: We did not observe any association between periodontal disease and breast cancer risk. Impact: Given inconsistent findings in the literature, further research with standardized clinical measures of periodontitis is warranted.