Is Hodgkin Lymphoma Associated with Hepatitis B and C Viruses? A Systematic Review and Meta-Analysis
A partir d'une revue systématique de la littérature publiée jusqu'en mars 2021 (9 études, 1 762 patients), cette méta-analyse évalue l'association entre une infection par le virus de l'hépatite B ou C et le risque de lymphome de Hodgkin
Background: Apart from the Epstein-Barr virus (EBV), the etiology of the hematological malignancy, Hodgkin lymphoma (HL) is not well defined. Hepatitis B and C viruses (HBV, HCV) are associated with some lymphoproliferative diseases with similarities to HL. Methods: We performed a systematic review and meta-analysis, by searching Embase, MEDLINE, and Web of Science databases on March 9, 2021, for studies reporting a measure of association for HBV and HL or HCV and HL. We calculated pooled relative risks (RRs) and their 95% confidence intervals (CIs). Results: Pooling nine HBV studies with 1,762 HL cases yielded an RR of 1.39 (95% CI: 1.00-1.94) and pooling 15 HCV studies with 4,837 HL cases resulted in an RR of 1.09 (95% CI: 0.88-1.35). Meta-analyzing by study design, hepatitis detection method, and region, revealed two subgroups with statistically significant associations - HCV studies that, employed hospital-based controls and/or were conducted in the West Pacific. No included study assessed age or EBV tumor status in relation to HL. Conclusions: While we did not find an association between HBV or HCV and HL, research assessing the impact of age and EBV tumor status was lacking. Impact: The effect of HBV or HCV infection in the development of HL remains unclear.