Radioactive Iodine Treatment in Hyperthyroidism and Cancer Mortality—A Still Controversial Issue
A partir d'une revue systématique de la littérature publiée jusqu'en octobre 2020 (12 études observationnelles, 479 452 participants), cette méta-analyse évalue l'association entre une exposition à l'iode radioactif pour traiter l'hyperthyroïdie et le risque de cancer, ainsi que la mortalité associée
Hyperthyroidism is a severe condition of thyroid hormone excess. Graves disease (GD), toxic multinodular goiter, and toxic adenoma are the most common causes of hyperthyroidism in younger individuals living in areas with iodine sufficiency and in older individuals in iodine-deficient regions. Hyperthyroidism has been associated with an increased risk of coronary heart disease mortality and incident atrial fibrillation, even in patients with subclinical hyperthyroidism with an undetectable serum thyroid-stimulating hormone level but particularly in older patients and in those with underlying heart diseases. Therefore, fast and effective control of hyperthyroidism is necessary to avoid adverse outcomes.
JAMA Network Open , éditorial en libre accès, 2020