Characterising 18F-fluciclovine uptake in breast cancer through the use of dynamic PET/CT imaging
Menée sur 39 patientes atteintes d'un cancer invasif du sein (âge : supérieur à 40 ans), cette étude analyse, en fonction du sous-type et du grade de la tumeur, la cinétique de la consommation de la fluciclovine 18F par les cellules cancéreuses dans le cadre d'une tomographie numérique par émission de positrons
Background : 18F-fluciclovine is a synthetic amino acid positron emission tomography (PET) radiotracer that is approved for use in prostate cancer. In this clinical study, we characterised the kinetic model best describing the uptake of 18F-fluciclovine in breast cancer and assessed differences in tracer kinetics and static parameters for different breast cancer receptor subtypes and tumour grades.
Methods : Thirty-nine patients with pathologically proven breast cancer underwent 20-min dynamic PET/computed tomography imaging following the administration of 18F-fluciclovine. Uptake into primary breast tumours was evaluated using one- and two-tissue reversible compartmental kinetic models and static parameters.
Results : A reversible one-tissue compartment model was shown to best describe tracer uptake in breast cancer. No significant differences were seen in kinetic or static parameters for different tumour receptor subtypes or grades. Kinetic and static parameters showed a good correlation.
Conclusions : 18F-fluciclovine has potential in the imaging of primary breast cancer, but kinetic analysis may not have additional value over static measures of tracer uptake.
British Journal of Cancer , article en libre accès, 2021