Incidence of malignancies among patients with chronic hepatitis B in US health care organizations, 2006–2018
Menée à l'aide de données 2006-2018 des registres américains des cancers et menée auprès de 5 773 personnes infectées par le virus de l'hépatite B, cette étude analyse l'association entre cette infection et le risque de cancer autre que le carcinome hépatocellulaire
Hepatitis B virus (HBV) infection causes hepatocellular carcinoma but its association with other cancers is not well established. We compared age-adjusted incidence of primary cancers among 5,773 HBV-infected persons with US cancer registries during 2006–2018. Compared with the US population, substantially higher incidence among HBV-infected persons was observed for hepatocellular carcinoma (Standardized rate ratio [SRR] 30.79), gastric (SRR 7.95), neuroendocrine (SRR 5.88), cholangiocarcinoma (SRR 4.62), and ovarian (SRR 3.72) cancers, and non-Hodgkin lymphoma (SRR 2.52). Clinicians should be aware of a heightened potential for certain non-hepatic malignancies among hepatitis B patients, as earlier diagnosis favors improved survival.