Pesticide residue intake from fruit and vegetable consumption and risk of glioma
Menée à partir de données 1998-2016 des cohortes "the Nurses’ Health Studies" et "the Health Professionals Follow-Up Study" (durée de suivi : 2 745 862 personnes-années), cette étude analyse l'association entre un apport de résidus de pesticides provenant de la consommation fruits et légumes et le risque de gliome (275 cas)
Several studies have identified positive associations between pesticides and glioma. We aimed to determine whether intake of pesticide residues from fruits and vegetables (FV) was associated with glioma. Within three prospective cohorts from 1998-2016—the Nurses’ Health Study (NHS), Nurses’ Health Study II (NHSII), and Health Professionals Follow-Up Study (HPFS)—we computed multivariable-adjusted (MV) hazard ratios (HR) and 95% confidence intervals (CI) for glioma by quintiles of intake of low and high pesticide residue FVs using Cox proportional hazards regression. FVs were categorized as high or low residue using a validated method based on pesticide surveillance data. We confirmed 275 glioma cases across 2,745,862 person-years. A significant association was observed between intake of high-residue FVs and glioma in NHS (MVHR=2.99, 95%CI:1.38-6.44 comparing highest to lowest quintile, p-trend=0.02). This was not identified in NHSII (MVHR=0.52, 95%CI:0.19-1.45, p-trend=0.20) or HPFS (MVHR=1.01, 95%CI:0.42-2.45, p-trend=0.39). No significant associations were observed by intake of low-residue FVs. Overall FV intake was not significantly associated with glioma in any cohort. We found no evidence for an inverse relation of FV intake with glioma. Although limited in power, this study suggests a possible association between FV pesticide residue intake and risk of glioma that merits further study.