The association of dietary fibre intake and the IL13 rs20541 polymorphism with the risk of gastric cancer: a case-control study in Korea
Menée en Corée auprès de 756 témoins et 377 patients atteints d'un cancer gastrique, cette étude évalue l'association entre un apport élevé en fibres alimentaires et le risque de développer la maladie, puis analyse l'effet, sur cette association, du polymorphisme à simple nucléotide rs20541 du gène IL13
Background: The beneficial effect of fibre intake on reducing the risk of gastric cancer (GC) has been emphasized in recent years; however, the findings from the existing literature have been ambiguous. Fibre and anti-inflammatory cytokines are associated with GC through inflammation. We investigated whether a higher fibre intake reduces GC risk and whether the IL13 rs20541 single-nucleotide polymorphism interacts with fibre intake to modify GC risk. Method: In this case-control study, 377 cases and 756 controls were included to assess the effects of fibre intake and the IL13 rs20541-fibre interaction on GC risk. We collected information on fibre consumption by using a semi-quantitative food frequency questionnaire. The presence of IL13 rs20541 was determined through genetic analysis. Results: A negative association between fibre intake and GC risk was observed (odds ratio (OR) = 0.37, 95% confidence interval (CI) = 0.24–0.57, P for trend < 0.001). However, the significant association seemed to be limited to males (OR = 0.28, 95% CI = 0.16–0.50, p for trend < 0.001). Although a non-significant association between IL13 rs20541 and GC risk was found (OR = 0.95, 95% CI = 0.71–1.26), we identified that individuals with a minor allele of IL13 rs20541 (AA/AG) and higher fibre intake had a lower GC risk than those with a minor allele and lower fibre intake (OR (95% CI) was 0.24 (0.12–0.45), P interaction = 0.024). Conclusion: Our findings suggested a protective effect of fibre against GC carcinogenesis. However, fibre intake seemed to have a greater effect in individuals with a minor allele of IL13 rs20541 (AA/AG).