Adult-Attained Height and Colorectal Cancer Risk: A Cohort Study, Systematic Review and Meta-Analysis
A partir d'une revue systématique de la littérature publiée jusqu'en août 2020 (47 études), cette méta-analyse évalue l'association entre la taille atteinte à l'âge adulte et le risque de cancer ou d'adénome colorectal
Background: The influence of anthropometric characteristics on colorectal neoplasia biology is unclear. We conducted a systematic review and meta-analysis to determine if adult-attained height is independently associated with the risk of colorectal cancer or adenoma. Methods: We searched MEDLINE, EMBASE, the Cochrane Library, and Web of Science from inception to August 2020 for studies on the association between adult-attained height and colorectal cancer or adenoma. The original data from the Johns Hopkins Colon Biofilm study was also included. The overall hazard ratio/odds ratio of colorectal cancer/adenoma with increased height was estimated using random-effects meta-analysis. Results: We included 47 observational studies involving 280,644 colorectal cancer and 14,139 colorectal adenoma cases. Thirty-three studies reported data for colorectal cancer incidence per 10-cm increase in height; 19 yielded a hazard ratio (HR) of 1.14 (95% confidence interval [CI], 1.11 to 1.17, P<0.001), and 14 engendered an odds ratio (OR) of 1.09 (95% CI, 1.05 to 1.13, P<0.001). Twenty-six studies compared colorectal cancer incidence between individuals within the highest versus the lowest height percentile; 19 indicated an HR of 1.24 (95% CI, 1.19 to 1.30, P<0.001), and seven resulting in an OR of 1.07 (95% CI, 0.92 to 1.25, P=0.39). Four studies reported data for assessing colorectal adenoma incidence per 10-cm increase in height, showing an overall OR of 1.06 (95% CI, 1.00 to 1.12, P=0.03). Conclusions: Greater adult attained height is associated with an increased risk of colorectal cancer and adenoma. Impact: Height should be considered as a risk factor for colorectal cancer screening.