A Meta-Analysis of Calcium Intake and Risk of Glioma
A partir d'une revue systématique de la littérature publiée jusqu'en août 2021 (4 études), cette méta-analyse évalue l'association entre l'apport en calcium et le risque de tumeur cérébrale
Background: A meta-analysis was conducted to investigate the correlation between calcium intake and the risk of brain tumors (especially glioma). Methods: The PubMed, Web of Science, and Embase databases were searched for relevant papers on the association between calcium intake and glioma as of August 22, 2021. The odds ratio (OR) with a 95% confidence interval (CI) was calculated using a random-effects model. Egger?s test was conducted to assess publication bias. Results: The meta-analysis includes four studies. The meta-analysis showed that calcium intake and the risk of brain tumors have a significant negative relationship (OR = 0.28; 95% CI: 0.11 to 0.72; P?=?0.008). Dose-response analysis showed that for every 100?mg/day increase in calcium intake, the risk of glioma decreased by 7% (OR = 0.93; 95% CI: 0.88 to 0.98). In addition, compared with humans without calcium intake, when calcium intake is 455?mg/day, 800?mg/day and 1000?mg/day, the risk of glioma is 0.65 (95% CI 0.43, 0.97), 0.55 (95% CI 0.37, 0.82) and 0.37 (95% CI 0.15, 0.86). Conclusion: There is a significant negative association between calcium intake and brain tumors (especially gliomas), but more high-quality studies are needed to verify these results.
Nutrition and Cancer 2022