Multiple pathogens and prostate cancer
A partir d'une revue systématique de la littérature publiée jusqu'en 2021, cette étude analyse le rôle de différents agents pathogènes ou inflammatoires dans la carcinogenèse prostatique
Background: The aim of this review is to consider whether multiple pathogens have roles in prostate cancer. Methods: We have reviewed case control studies in which infectious pathogens in prostate cancer were compared to normal and benign prostate tissues. We also reviewed additional evidence from relevant published articles. Results: We confirmed that high risk human papilloma viruses are a probable cause of prostate cancer. We judged Escherichia coli, Cutibacterium acnes, Neisseria gonorrhoea, Herpes simplex, Epstein Barr virus and Mycoplasmas as each having possible but unproven roles in chronic prostatic inflammation and prostate cancer. We judged Cytomegalovirus, Chlamydia trachomatis, Trichomonas vaginalis and the Polyoma viruses as possible but unlikely to have a role in prostate cancer. Conclusions and actions: The most influential cause of prostate cancer appears to be infection induced chronic inflammation. Given the high prevalence of prostate cancer it is important for action to can be taken without waiting for additional conclusive evidence.