Parental age and childhood lymphoma and solid tumor risk: A literature review and meta-analysis
A partir d'une revue de la littérature publiée jusqu'en mars 2022 (15 études, 30 323 patients), cette méta-analyse évalue l'association entre l'âge des parents et le risque de tumeur solide pédiatrique
Though advanced parental age has been definitively linked to pediatric acute lymphoblastic leukemia (ALL), studies of parental age and pediatric solid tumors have not reached firm conclusions. This analysis aimed to elucidate the relationship between parental age and pediatric solid tumors through meta-analysis of existing studies based in population registries.We searched Medline (PubMed) and Embase for registry-based studies of parental age and solid tumors through March 2022. We performed random-effects meta-analysis to estimate pooled effects and 95% confidence intervals. All statistical tests were two-sided.A total of fifteen studies covering ten childhood solid tumor types (a total of 30323 cases and 3,499,934 controls) were included in this analysis. A five-year increase in maternal age was associated with an increased risk of combined CNS tumors (OR: 1.07, 95% CI: 1.04–1.10), ependymoma (OR: 1.19, 95% CI: 1.09–1.31), astrocytoma (OR: 1.10, 95% CI: 1.05–1.15), rhabdomyosarcoma (OR: 1.14, 95% CI: 1.03–1.25), and germ cell tumors (OR: 1.06, 95% CI: 1.00–1.12). A five-year increase in paternal age was associated with an increased risk of non-Hodgkin’s Lymphoma (OR: 1.06, 95% CI: 1.00–1.12).This meta-analysis of registry-based analyses of parental age and childhood cancer supports the association between older maternal age and certain childhood solid cancers. There is also some evidence that paternal age may be associated with certain cancers such as non-Hodgkin’s lymphoma. However, as maternal and paternal age are highly correlated, disentangling potential independent causal effects of either factor will require very large studies with extensive data on potential confounders.