Precancerous cervical lesions caused by non-vaccine-preventable HPV types after vaccination with the bivalent AS04-adjuvanted HPV vaccine: an analysis of the long-term follow-up study from the randomised Costa Rica HPV Vaccine Trial
Mené entre 2004 et 2005 au Costa Rica sur 7 466 femmes âgées de 18 à 25 ans et en bonne santé (durée médiane de suivi : 11,1 ans), cet essai randomisé évalue l'efficacité du vaccin bivalent contre le papillomavirus humain (HPV16/18) sur le risque de développer des néoplasies cervicales intraépithéliales de haut grade (CIN2+, CIN3+ ou supérieur) attribuées à d'autres types de HPV
In women vaccinated against human papillomavirus (HPV), reductions in cervical disease and related procedures results in more women having intact transformation zones, potentially increasing the risk of cervical lesions caused by non-vaccine-preventable HPV types, a phenomenon termed clinical unmasking. We aimed to evaluate HPV vaccine efficacy against cervical intraepithelial neoplasia grade 2 or worse (CIN2+) and cervical intraepithelial neoplasia grade 3 or worse (CIN3+) attributed to non-preventable HPV types in the long-term follow-up phase of the Costa Rica HPV Vaccine Trial (CVT).