Anthropometric traits and risk of multiple myeloma: a pooled prospective analysis
Menée à l'aide des données de 6 études américaines portant sur 544 016 personnes (durée de suivi : 20-37 ans), cette étude analyse l'association entre l'indice de masse corporelle chez l'adulte jeune (18-21 ans), l'indice de masse corporelle chez l'adulte, le tour de taille, la masse grasse et le risque de myélome multiple (2 756 cas)
Background: Obesity is a risk factor for multiple myeloma (MM), yet results of prior studies have been mixed regarding the importance of early and/or later adult obesity; other measures of body composition have been less well studied. Methods: We evaluated associations of early adult (ages 18–21) and usual adult body mass index (BMI), waist circumference, and predicted fat mass with MM by pooling data from six U.S. prospective cohort studies comprising 544,016 individuals and 2756 incident diagnoses over 20–37 years of follow-up. We used Cox proportional hazards models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations, adjusted for age and other risk factors. Results: Each 5 kg/m2 increase in usual adult BMI was associated with a 10% increased risk of MM (HR: 1.10; 95% CI: 1.05–1.15). Positive associations were also noted for early adult BMI (HR per 5 kg/m2: 1.14; 95% CI: 1.04–1.25), height (HR per 10 cm: 1.28; 95% CI: 1.20–1.37), waist circumference (HR per 15 cm: 1.09; 95% CI: 1.00–1.19), and predicted fat mass (HR per 5 kg: 1.06; 95% CI: 1.01–1.11). Conclusions: These findings highlight the importance of avoidance of overweight/obesity and excess adiposity throughout adulthood as a potential MM risk-reduction strategy.