Cancer vaccines: Building a bridge over troubled waters
Cet article présente les mécanismes impliqués dans l'immunité naturelle, décrit le microenvironnement immunitaire de la tumeur, identifie les défis à relever pour développer des vaccins dirigés contre les cellules cancéreuses puis passe en revue les avancées technologiques récentes permettant de faciliter le développement de ces vaccins
Cancer vaccines aim to direct the immune system to eradicate cancer cells. Here we review the essential immunologic concepts underpinning natural immunity and highlight the multiple unique challenges faced by vaccines targeting cancer. Recent technological advances in mass spectrometry, neoantigen prediction, genetically and pharmacologically engineered mouse models, and single-cell omics have revealed new biology, which can help to bridge this divide. We particularly focus on translationally relevant aspects, such as antigen selection and delivery and the monitoring of human post-vaccination responses, and encourage more aggressive exploration of novel approaches.
Cell , résumé, 2021