A novel circulating miRNA panel for non-invasive ovarian cancer diagnosis and prognosis
Menée à partir d'échantillons sanguins prélevés sur 99 témoins et 145 patientes présentant des lésions cancéreuses ou bénignes de l'ovaire, cette étude identifie un panel de 7 micro-ARNs circulants pour diagnostiquer un cancer de l'ovaire et établir un pronostic
Background : Ovarian cancer (OC) is an aggressive disease, primarily diagnosed in late stages with only 20% of patients surviving more than 5 years after diagnosis. There is a pending need to improve current diagnostics and prognostics.
Methods : In this study, we investigated total circulating cell-free microRNA (cf-miRNA) levels as well as a panel of cf-miRNAs in the plasma of OC patients (n = 100), patients with benign lesions (n = 45) and healthy controls (n = 99).
Results : High levels of cf-miRNAs correlated with unfavourable clinical features and were an independent prognosticator of patient survival. By mining NGS data, we identified a signature panel of seven individual cf-miRNAs which could distinguish controls from benign cases with an AUC of 0.77 and controls from cancer cases with an AUC of 0.87. Importantly, in combination with the current gold-standard marker, CA-125, the panel could predict early OC with an AUC of 0.93.
Conclusion : Our findings highlight the potential of cf-miRNA levels as well as individual cf-miRNAs for OC diagnosis and prognosis that warrants further clinical evaluation.
British Journal of Cancer , article en libre accès, 2022