A flexible electronic strain sensor for the real-time monitoring of tumor regression
Menée à l'aide de deux modèles murins de cancer, cette étude met en évidence l'intérêt d'un capteur électronique entièrement flexible et extensible pour mesurer en temps réel le volume tumoral dans le cadre d'un traitement anticancéreux
Assessing the efficacy of cancer therapeutics in mouse models is a critical step in treatment development. However, low-resolution measurement tools and small sample sizes make determining drug efficacy in vivo a difficult and time-intensive task. Here, we present a commercially scalable wearable electronic strain sensor that automates the in vivo testing of cancer therapeutics by continuously monitoring the micrometer-scale progression or regression of subcutaneously implanted tumors at the minute time scale. In two in vivo cancer mouse models, our sensor discerned differences in tumor volume dynamics between drug- and vehicle-treated tumors within 5 hours following therapy initiation. These short-term regression measurements were validated through histology, and caliper and bioluminescence measurements taken over weeklong treatment periods demonstrated the correlation with longer-term treatment response. We anticipate that real-time tumor regression datasets could help expedite and automate the process of screening cancer therapies in vivo. An elastic sensor autonomously detects micrometer-scale tumor volume changes in vivo, enabling real-time regression analysis.
Science Advances , article en libre accès, 2021