Early radiologic signal of responsiveness to immune checkpoint blockade in microsatellite-stable/mismatch repair-proficient metastatic colorectal cancer
Menée sur 76 patients atteints d'un cancer colorectal métastatique non résécable sans instabilité des microsatellites et sans dysfonctionnement du système de réparation des mésappariements de l'ADN, cette étude évalue l'association entre le taux de réduction des lésions cancéreuses, évalué par examen radiologique, et la réponse tumorale au nivolumab
Background : Immune checkpoint blockade (ICB) results in radiologic tumour response dynamics that differ from chemotherapy efficacy measures and require an early signal of clinical utility.
Methods : Previously untreated, unresectable microsatellite-stable (MSS)/mismatch repair-proficient (pMMR) colorectal cancer (CRC) patients were randomly assigned to the oxaliplatin-based Nordic FLOX regimen (control arm) or repeat sequential two FLOX cycles and two ICB cycles (experimental arm). The radiologic response was assessed every 8 weeks. In this post hoc analysis, we explored early target lesion (TL) dynamics as indicator of ICB responsiveness. Progression-free survival (PFS) was the primary endpoint.
Results : Using a landmark analysis approach, we categorised experimental-arm patients into
≥
10% (N = 19) or <10% (N = 16) TL reduction at the first post-baseline response assessment. Median PFS for the groups was 16.0 (95% confidence interval (CI), 12.3–19.7) and 3.9 months (95% CI, 2.3–5.5), respectively, superior and inferior (both P < 0.01) to the median PFS of 9.8 months (95% CI, 4.9–14.7) for control arm patients (N = 31).
Conclusions : Radiologic TL reduction of
≥
10% at the first post-baseline response assessment identified patients with ICB-responsive metastatic MSS/pMMR-CRC. This pragmatic measure may be used to monitor patients in investigational ICB schedules, enabling early treatment adaptation for unresponsive cases.
Trial registration : ClinicalTrials.gov number, NCT03388190 (02/01/2018).
British Journal of Cancer , article en libre accès, 2022