Cancer risk among HIV-exposed uninfected children in the United States
Menée aux Etats-Unis à partir de données 1990-2017 portant sur 13 617 enfants, cette étude analyse l'association entre une exposition in utéro au VIH et le risque de cancer chez les patients séronégatifs à la naissance
In utero exposure to didanosine was associated with increased risk of brain cancer in a French study. We used United States health department records to assess cancer risk among 13 617 children exposed to HIV in utero, who remained HIV-uninfected after birth (1990–2017). Risk of brain tumors was borderline elevated among these children (standardized incidence ratio 2.2, 95% confidence interval 0.8–4.8, P = 0.12, based on six cases). Risk was not significantly increased for leukemia or other cancers.
AIDS 2022