Randomised controlled trial of breast cancer and multiple disease prevention weight loss programmes vs written advice amongst women attending a breast cancer family history clinic
Mené sur 210 femmes obèses ou en surpoids et présentant un risque modéré ou élevé de cancer du sein (âge : 30 ans ou plus), cette étude évalue, par rapport à des conseils comportementaux écrits et du point de vue de la perte de poids et de l'évolution des comportements de santé, l'efficacité de deux programmes de prévention, l'un visant à réduire spécifiquement le risque de cancer du sein, l'autre destiné à réduire le risque de développer trois types de maladie (cancer du sein, maladies cardiovasculaires et diabète de type 2)
Background : Overweight and obesity are common amongst women attending breast cancer Family History, Risk and Prevention Clinics (FHRPCs). Overweight increases risk of breast cancer (BC) and conditions including1 cardiovascular disease (CVD) and type-2 diabetes (T2D). Clinics provide written health behaviour advice with is likely to have minimal effects. We assessed efficacy of two remotely delivered weight loss programmes vs. written advice. Method : 210 women with overweight or obesity attending three UK FHRPCs were randomised to either a BC prevention programme (BCPP) framed to reduce risk of BC (n = 86), a multiple disease prevention programme (MDPP) framed to reduce risk of BC, CVD and T2D (n = 87), or written advice (n = 37). Change in weight and health behaviours were assessed at 12-months. Results : Weight loss at 12 months was
−
6.3% (
−
8.2,
−
4.5) in BCPP,
−
6.0% (
−
7.9,
−
4.2) in MDPP and
−
3.3% (
−
6.2,
−
0.5) in the written group (p = 0.451 across groups). The percentage losing
≥
10% weight in these groups were respectively 34%, 23% and 14% (p = 0.038 across groups). Discussion : BCPP and MDPP programmes resulted in more women achieving
≥
10% weight loss, but no evidence of additional benefits of MDPP. A multicentre RCT to test the BCPP across UK FHRPCs is warranted.