The association between poor oral health and risk of breast cancer in the UK Biobank
Menée à l'aide de données de la "UK Biobank" portant sur 234 363 femmes, cette étude analyse l'association entre des problèmes de santé bucco-dentaire et le risque de cancer du sein
Purpose: Specific oral health conditions may be risk factors for breast cancer. This study aimed to investigate the associations of oral health conditions with breast cancer risk. Methods: A total of 234,363 women from the UK Biobank prospective cohort were included in this study. We examined the association of self-reported painful/bleeding gums, loose teeth, mouth ulcers, toothache, and use of dentures with the risk of breast cancer. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) for the associations were calculated with adjustment for multiple confounders. Results: No associations of self-reported painful/bleeding gums (HR = 1.04, 95% CI 0.98–1.10), loose teeth (HR = 0.92, 95% CI 0.82–1.02), mouth ulcers (HR = 0.99, 95% CI 0.93–1.06), toothache (HR = 1.03, 95% CI 0.92–1.14), or denture use (HR = 0.96, 95% CI 0.91–1.02) with breast cancer risk were found. No statistical heterogeneity was observed in analyses stratified by baseline smoking and menopausal status. Conclusion: We observed no association between self-reported oral health conditions with the risk of breast cancer. Additional research with clinical examinations or oral health biomarkers in diverse populations is warranted.