Alcohol consumption and socioeconomic status associated with the risk of kidney cancer in a large Australian cohort study
Menée à l'aide de données portant sur une cohorte australienne de 267 357 participants (durée médiane de suivi : 5,4 ans), cette étude analyse l'association entre une consommation d'alcool et le risque de cancer du rein (497 cas), en fonction du statut socioéconomique
Purpose: Studies have shown an inverse association between alcohol consumption and kidney cancer risk. We postulate that this inverse association may be further influenced by other risk factors.
Methods: We used an Australian cohort, the 45 and Up Study recruited between 2005-2009 to investigate the association between alcohol consumption, and other potential risk factors and kidney cancer incidence. The median follow up was 5.4 years.
Results: Of the 267 357 participants aged ≥45 years living in New South Wales, 497 were diagnosed with kidney cancer. There was a significant inverse association between alcohol consumption and risk of kidney cancer (p = 0.027), and a significant inverse dose-response relationship (p=0.011). There was significant interaction between alcohol consumption and socioeconomic status (p interaction = 0.001). Participants residing in higher socioeconomic areas (the two most advantaged quintiles) who consumed 8-10 drinks or >10 drinks per week, respectively, had a lower risk of kidney cancer compared to the group who consumed 1-4 drinks per week (HR 0.34, 95% CI 0.15-0.76, HR 0.51, 95% CI 0.31-0.83) with a dose-response trend of HR 0.62 (95% CI 0.42-0.93) per 7 drink increase in weekly alcohol consumption.
Conclusion: There could be an inverse association between alcohol consumption and risk in those residents in higher socioeconomic areas.
Annals of Epidemiology , article en libre accès, 2023