Analysis of Time Between Skin Lesion and Lymph Node Biopsies and Lymph Node Metastasis in Patients With Melanoma
Menée sur 642 patients atteints d'un mélanome (âge médian : 60 ans : 57 % d'hommes), cette étude évalue l'effet du délai entre le diagnostic et l'intervention chirurgicale sur le statut des ganglions lymphatiques à la résection
The standard of care treatment for patients with stage T1b or higher cutaneous melanoma without radiographic or clinical evidence of metastatic disease is wide local excision (WLE) and sentinel lymph node biopsy (SLNB).1 The immediate purposes of WLE and SLNB are prognostication, staging via identification of occult metastatic disease, and guiding decisions for adjuvant systemic treatment.2,3 It is unclear, however, how long a patient can safely wait between diagnosis and surgery before it can affect disease staging. We sought to determine whether increasing time to surgery was associated with sentinel lymph node status.
JAMA Network Open , article en libre accès, 2022